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Class: ModelToDiseaseAssociationMixin

Description: This mixin is used for any association class for which the subject (source node) plays the role of a 'model', in that it recapitulates some features of the disease in a way that is useful for studying the disease outside a patient carrying the disease
classDiagram class ModelToDiseaseAssociationMixin ModelToDiseaseAssociationMixin <|-- GeneAsAModelOfDiseaseAssociation ModelToDiseaseAssociationMixin <|-- VariantAsAModelOfDiseaseAssociation ModelToDiseaseAssociationMixin <|-- GenotypeAsAModelOfDiseaseAssociation ModelToDiseaseAssociationMixin <|-- CellLineAsAModelOfDiseaseAssociation ModelToDiseaseAssociationMixin <|-- OrganismalEntityAsAModelOfDiseaseAssociation ModelToDiseaseAssociationMixin : object ModelToDiseaseAssociationMixin --|> NamedThing : object ModelToDiseaseAssociationMixin : predicate ModelToDiseaseAssociationMixin : subject ModelToDiseaseAssociationMixin --|> NamedThing : subject

Slots

Name Cardinality and Range Inheritance Examples
subject:
The entity that serves as the model of the disease. This may be an organism, a strain of organism, a genotype or variant that exhibits similar features, or a gene that when mutated exhibits features of the disease
1
NamedThing		 direct
predicate:
The relationship to the disease 		1
Uriorcurie		 direct
object:
connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
NamedThing		 direct

Mixin Usage

mixed into description
GeneAsAModelOfDiseaseAssociation An association in which a gene (e.g., a model-organism ortholog of a known disease gene) serves as a model of a human disease - for example, because mutants of the gene recapitulate core features of the disease.
VariantAsAModelOfDiseaseAssociation An association in which a sequence variant serves as a model of a disease, recapitulating features relevant for studying the disease outside of a patient who carries it.
GenotypeAsAModelOfDiseaseAssociation An association in which a genotype serves as a model of a disease, recapitulating features relevant for studying the disease outside of a patient who carries it.
CellLineAsAModelOfDiseaseAssociation An association in which a cell line - typically derived from an organismal entity with a disease state - serves as a model for that disease in experimental settings.
OrganismalEntityAsAModelOfDiseaseAssociation An association in which an organismal entity (e.g., a strain or breed) serves as a model of a disease, either because it has a natural predisposition to the disease or was bred or engineered specifically to recapitulate it.

LinkML Source

name: model to disease association mixin
description: This mixin is used for any association class for which the subject (source
  node) plays the role of a 'model', in that it recapitulates some features of the
  disease in a way that is useful for studying the disease outside a patient carrying
  the disease
from_schema: https://w3id.org/biolink/vocab/
mixin: true
slots:
- subject
- predicate
- object
slot_usage:
  subject:
    name: subject
    description: The entity that serves as the model of the disease. This may be an
      organism, a strain of organism, a genotype or variant that exhibits similar
      features, or a gene that when mutated exhibits features of the disease
  predicate:
    name: predicate
    description: The relationship to the disease
    subproperty_of: model of