Slot: subject_aspect_qualifier

Description: Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept. The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association. This qualifier specifies a change in the subject of an association (aka: statement).

Domain: Association
Range: GeneOrGeneProductOrChemicalEntityAspectEnum

Inheritance

• association_slot
  • qualifier
    • aspect_qualifier
      • subject_aspect_qualifier

Applicable Classes

Name	Description	Modifies Slot
GeneAffectsChemicalAssociation	Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.)	yes
FeatureOrDiseaseQualifiersToEntityMixin	Qualifiers for disease or phenotype to entity associations.	no
CausalGeneToDiseaseAssociation	An association between a gene and a disease where variation in the gene has been shown to have a causal role in the disease.	no
GeneToDiseaseAssociation	An association between a gene or gene product and a disease, where variation in the gene is correlated with the disease.	yes
ChemicalGeneSensitivityAssociation	Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation.	yes
PredicateMapping	A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place.	no
ChemicalAffectsBiologicalEntityAssociation	Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)	yes
MacromolecularMachineHasSubstrateAssociation	Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein.	no
EntityToFeatureOrDiseaseQualifiersMixin	Qualifiers for entity to disease or phenotype associations.	no
EntityToFeatureOrVariantQualifiersMixin	Qualifiers for entity to variant associations.	no
GeneToPhenotypicFeatureAssociation	An association between a gene or gene product and a phenotypic feature, where variation in the gene is correlated with the phenotypic feature.	yes
GeneToGeneAssociation	parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction.	no
NamedThingAssociatedWithLikelihoodOfNamedThingAssociation	An association in which the subject entity is linked to the likelihood of the object entity occurring, manifesting, or being observed. Subject and object may each be qualified by aspect and context, and the association may be further qualified by a population context.	yes
CorrelatedGeneToDiseaseAssociation	An association between a gene (or gene product) and a disease for which the gene is statistically correlated with the disease rather than asserted as causal. Such associations typically derive from GWAS, co-occurrence analyses, or other statistical methods, and are annotated with scores such as a z-score or a diseases confidence score.	no
EntityToFeatureOrGeneQualifiersMixin	Qualifiers for entity to gene associations.	no

Example values

Slot Name	Value
subject_aspect_qualifier	stability
subject_aspect_qualifier	abundance
subject_aspect_qualifier	expression
subject_aspect_qualifier	exposure

LinkML Source

name: subject aspect qualifier
description: 'Composes with the core concept to describe new concepts of a different
  ontological type. e.g. a process in which the core concept participates, a function/activity/role
  held by the core concept, or a characteristic/quality that inheres in the core concept.  The
  purpose of the aspect slot is to indicate what aspect is being affected in an ''affects''
  association.  This qualifier specifies a change in the subject of an association
  (aka: statement).'
examples:
- value: stability
- value: abundance
- value: expression
- value: exposure
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: aspect qualifier
domain: association
alias: subject_aspect_qualifier
domain_of:
- predicate mapping
- gene to gene association
- named thing associated with likelihood of named thing association
- macromolecular machine has substrate association
- chemical affects biological entity association
- chemical gene sensitivity association
- gene affects chemical association
- entity to feature or disease qualifiers mixin
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
- gene to phenotypic feature association
- gene to disease association
- causal gene to disease association
- correlated gene to disease association
range: GeneOrGeneProductOrChemicalEntityAspectEnum