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Class: EntityToFeatureOrDiseaseQualifiersMixin

Description: Qualifiers for entity to disease or phenotype associations.
classDiagram class EntityToFeatureOrDiseaseQualifiersMixin FrequencyQualifierMixin <|-- EntityToFeatureOrDiseaseQualifiersMixin EntityToFeatureOrDiseaseQualifiersMixin <|-- ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation EntityToFeatureOrDiseaseQualifiersMixin <|-- ChemicalOrDrugOrTreatmentAdverseEventAssociation EntityToFeatureOrDiseaseQualifiersMixin <|-- ChemicalOrDrugOrTreatmentSideEffectAssociation EntityToFeatureOrDiseaseQualifiersMixin <|-- EntityToPhenotypicFeatureAssociationMixin EntityToFeatureOrDiseaseQualifiersMixin <|-- EntityToDiseaseAssociationMixin EntityToFeatureOrDiseaseQualifiersMixin : disease_context_qualifier EntityToFeatureOrDiseaseQualifiersMixin --|> Disease : disease_context_qualifier EntityToFeatureOrDiseaseQualifiersMixin : frequency_qualifier EntityToFeatureOrDiseaseQualifiersMixin : object EntityToFeatureOrDiseaseQualifiersMixin --|> NamedThing : object EntityToFeatureOrDiseaseQualifiersMixin : object_aspect_qualifier EntityToFeatureOrDiseaseQualifiersMixin --|> GeneOrGeneProductOrChemicalEntityAspectEnum : object_aspect_qualifier EntityToFeatureOrDiseaseQualifiersMixin : object_direction_qualifier EntityToFeatureOrDiseaseQualifiersMixin --|> DirectionQualifierEnum : object_direction_qualifier EntityToFeatureOrDiseaseQualifiersMixin : predicate EntityToFeatureOrDiseaseQualifiersMixin : qualified_predicate EntityToFeatureOrDiseaseQualifiersMixin : subject EntityToFeatureOrDiseaseQualifiersMixin --|> NamedThing : subject EntityToFeatureOrDiseaseQualifiersMixin : subject_aspect_qualifier EntityToFeatureOrDiseaseQualifiersMixin --|> GeneOrGeneProductOrChemicalEntityAspectEnum : subject_aspect_qualifier EntityToFeatureOrDiseaseQualifiersMixin : subject_direction_qualifier EntityToFeatureOrDiseaseQualifiersMixin --|> DirectionQualifierEnum : subject_direction_qualifier

Inheritance

Slots

Name Cardinality and Range Inheritance Examples
subject_aspect_qualifier:
Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept. The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association. This qualifier specifies a change in the subject of an association (aka: statement).
0..1
GeneOrGeneProductOrChemicalEntityAspectEnum		 direct stability, abundance, expression, exposure
subject_direction_qualifier:
Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement). 		0..1
DirectionQualifierEnum		 direct increased, downregulated
object_aspect_qualifier:
Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept. The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association. This qualifier specifies a change in the object of an association (aka: statement). 		0..1
GeneOrGeneProductOrChemicalEntityAspectEnum		 direct stability, abundance, expression, exposure
object_direction_qualifier:
Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement). 		0..1
DirectionQualifierEnum		 direct increased, downregulated
qualified_predicate:
Predicate to be used in an association when subject and object qualifiers are present and the full reading of the statement requires a qualification to the predicate in use in order to refine or increase the specificity of the full statement reading. Has a value from the Biolink 'related_to' hierarchy, for example, biolink:related_to, biolink:causes, biolink:treats This qualifier holds a relationship to be used instead of that expressed by the primary predicate, in a ‘full statement’ reading of the association, where qualifier-based semantics are included. This is necessary only in cases where the primary predicate does not work in a full statement reading. 		0..1
Uriorcurie		 direct biolink:causes
disease_context_qualifier:
A context qualifier representing a disease or condition in which a relationship expressed in an association took place. 		0..1
Disease		 direct MONDO:0004979, MONDO:0005148
frequency_qualifier:
a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject 		0..1
FrequencyValue		 FrequencyQualifierMixin
subject:
connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
NamedThing		 FrequencyQualifierMixin
predicate:
Has a value from the Biolink 'related_to' hierarchy. In RDF, this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats 		1
Uriorcurie		 FrequencyQualifierMixin
object:
connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
NamedThing		 FrequencyQualifierMixin

Mixin Usage

mixed into description
ChemicalOrDrugOrTreatmentToDiseaseOrPhenotypicFeatureAssociation This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the chemical or treatment is used to treat, or is being studied to treat, the disease or phenotypic feature.
ChemicalOrDrugOrTreatmentAdverseEventAssociation This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disease or phenotypic feature is an untoward medical occurrence that happens during treatment, whether or not considered related to the treatment.
ChemicalOrDrugOrTreatmentSideEffectAssociation This association defines a relationship between a chemical or treatment (or procedure) and a disease or phenotypic feature where the disease or phenotypic feature is an unintended, but predictable, secondary effect of the treatment.

LinkML Source

name: entity to feature or disease qualifiers mixin
description: Qualifiers for entity to disease or phenotype associations.
from_schema: https://w3id.org/biolink/vocab/
is_a: frequency qualifier mixin
mixin: true
slots:
- subject aspect qualifier
- subject direction qualifier
- object aspect qualifier
- object direction qualifier
- qualified predicate
- disease context qualifier