Slot: interacts_with (multivalued)
Description: holds between any two entities that directly or indirectly interact with each other in a physical or functional way.
Notes: A note on 'interacts with' vs 'affects': These are related but separate relationships. An interaction may or may not involve one interactor exerting an effect on the other. It simply indicates that two entities participate in a physical or functional relationship (e.g. molecular binding, genetic interactions such as epistasis, or pharmacological interactions in which the combined behavior of two drugs differs from that of either drug alone). An 'effect' may be mediated by an interaction or may arise without any direct interaction, through a chain of intermediary events. Any effect or causal influence must be asserted using a predicate in the affects or causes hierarchy. Please use a more specific child predicate of interacts with, either physically interacts with or genetically interacts with or pharmacologically interacts with.
Notes: A note on 'interacts with' vs 'affects': These are related but separate relationships. An interaction may or may not involve one interactor exerting an effect on the other. It simply indicates that two entities participate in a physical or functional relationship (e.g. molecular binding, genetic interactions such as epistasis, or pharmacological interactions in which the combined behavior of two drugs differs from that of either drug alone). An 'effect' may be mediated by an interaction or may arise without any direct interaction, through a chain of intermediary events. Any effect or causal influence must be asserted using a predicate in the affects or causes hierarchy. Please use a more specific child predicate of interacts with, either physically interacts with or genetically interacts with or pharmacologically interacts with.
Domain: NamedThing
Range: NamedThing
Inheritance
Mixin Usage
| mixed into | description | range | domain |
|---|---|---|---|
| physically_interacts_with | holds between two entities that make physical contact as part of some interaction. does not imply a causal relationship. | None | |
| regulates | A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation. Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction. | physical essence or occurrent |
LinkML Source
name: interacts with
description: holds between any two entities that directly or indirectly interact with
each other in a physical or functional way.
notes:
- 'A note on ''interacts with'' vs ''affects'': These are related but separate relationships.
An interaction may or may not involve one interactor exerting an effect on the other.
It simply indicates that two entities participate in a physical or functional relationship
(e.g. molecular binding, genetic interactions such as epistasis, or pharmacological
interactions in which the combined behavior of two drugs differs from that of either
drug alone). An ''effect'' may be mediated by an interaction or may arise without
any direct interaction, through a chain of intermediary events. Any effect or causal
influence must be asserted using a predicate in the affects or causes hierarchy.'
- Please use a more specific child predicate of interacts with, either physically
interacts with or genetically interacts with or pharmacologically interacts with.
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
exact_mappings:
- SEMMEDDB:INTERACTS_WITH
is_a: related to at instance level
mixin: true
domain: named thing
inherited: true
alias: interacts_with
symmetric: true
range: named thing
multivalued: true