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Slot: subject_direction_qualifier

Description: Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement).

Domain: Association
Range: DirectionQualifierEnum

Inheritance

Applicable Classes

Name Description Modifies Slot
GeneAffectsChemicalAssociation Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.) yes
FeatureOrDiseaseQualifiersToEntityMixin Qualifiers for disease or phenotype to entity associations. no
ChemicalGeneSensitivityAssociation Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation. yes
PredicateMapping A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place. no
ChemicalAffectsBiologicalEntityAssociation Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.) yes
MacromolecularMachineHasSubstrateAssociation Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein. no
EntityToFeatureOrDiseaseQualifiersMixin Qualifiers for entity to disease or phenotype associations. no
EntityToFeatureOrVariantQualifiersMixin Qualifiers for entity to variant associations. no
GeneToGeneAssociation parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction. no
EntityToFeatureOrGeneQualifiersMixin Qualifiers for entity to gene associations. no

Example values

Slot Name Value
subject_direction_qualifier increased
subject_direction_qualifier downregulated

LinkML Source

name: subject direction qualifier
description: 'Composes with the core concept (+ aspect if provided) to describe a
  change in its direction or degree. This qualifier qualifies the subject of an association
  (aka: statement).'
examples:
- value: increased
- value: downregulated
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: direction qualifier
domain: association
alias: subject_direction_qualifier
domain_of:
- predicate mapping
- gene to gene association
- macromolecular machine has substrate association
- chemical affects biological entity association
- chemical gene sensitivity association
- gene affects chemical association
- entity to feature or disease qualifiers mixin
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
range: DirectionQualifierEnum