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Slot: subject_direction_qualifier

Description: Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement).

Domain: Association
Range: DirectionQualifierEnum

Inheritance

Applicable Classes

Name Description Modifies Slot
PredicateMapping A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place. no
GeneToGeneAssociation parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction. no
MacromolecularMachineHasSubstrateAssociation Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein. no
ChemicalAffectsBiologicalEntityAssociation Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.) yes
ChemicalGeneSensitivityAssociation Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation. yes
GeneAffectsChemicalAssociation Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.) yes
EntityToFeatureOrDiseaseQualifiersMixin Qualifiers for entity to disease or phenotype associations. no
EntityToFeatureOrVariantQualifiersMixin Qualifiers for entity to variant associations. no
EntityToFeatureOrGeneQualifiersMixin Qualifiers for entity to gene associations. no
FeatureOrDiseaseQualifiersToEntityMixin Qualifiers for disease or phenotype to entity associations. no

Example values

Slot Name Value
subject_direction_qualifier increased
subject_direction_qualifier downregulated

LinkML Source

name: subject direction qualifier
description: 'Composes with the core concept (+ aspect if provided) to describe a
  change in its direction or degree. This qualifier qualifies the subject of an association
  (aka: statement).'
examples:
- value: increased
- value: downregulated
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: direction qualifier
domain: association
alias: subject_direction_qualifier
domain_of:
- predicate mapping
- gene to gene association
- macromolecular machine has substrate association
- chemical affects biological entity association
- chemical gene sensitivity association
- gene affects chemical association
- entity to feature or disease qualifiers mixin
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
range: DirectionQualifierEnum