Slot: pXC50
Description: In the context of molecular interactions and drug discovery, pXC50 is a generic, base 10 negative logarithmic measure of compound potency that unifies different types of half‑maximal concentration values into a single notation, where XC50 means “the concentration at which 50% of the maximal effect is observed”, and X is a placeholder for the type of effect being measured (e.g., inhibition or activation). The X in pXC50 is intentionally generic and can represent different assay endpoints.
Domain: NamedThing
Range: QuantityValue
Inheritance
- node_property
- pXC50
Applicable Classes
| Name | Description | Modifies Slot |
|---|---|---|
| ProteinLigandAssayResult | The type of study result describing the strength of interaction affinity - or enzymatic interaction - between a ligand and a target protein. Measured binding or enzymatic assay values are generally stated as the negative base 10 logarithm of the raw measurements. For instance (i.e., in a molecular interaction database like BindingDb) if a ligand inhibits a target protein with a pIC50 of 8.6, then the affinity parameter is pIC50 and the affinity value is 8.6. | no |
LinkML Source
name: pXC50
description: In the context of molecular interactions and drug discovery, pXC50 is
a generic, base 10 negative logarithmic measure of compound potency that unifies
different types of half‑maximal concentration values into a single notation, where
XC50 means “the concentration at which 50% of the maximal effect is observed”, and
X is a placeholder for the type of effect being measured (e.g., inhibition or activation).
The X in pXC50 is intentionally generic and can represent different assay endpoints.
from_schema: https://w3id.org/biolink/vocab/
is_a: node property
domain: named thing
domain_of:
- protein ligand assay result
range: quantity value