Slot: object_direction_qualifier

Description: Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement).

Domain: Association
Range: DirectionQualifierEnum

Inheritance

• association_slot
  • qualifier
    • direction_qualifier
      • object_direction_qualifier

Applicable Classes

Name	Description	Modifies Slot
FeatureOrDiseaseQualifiersToEntityMixin	Qualifiers for disease or phenotype to entity associations.	no
ChemicalGeneInteractionAssociation	describes an interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)	yes
GeneRegulatesGeneAssociation	Describes a regulatory relationship between two genes or gene products.	yes
ChemicalAffectsBiologicalEntityAssociation	Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)	yes
GeneToGeneAssociation	parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction.	no
MacromolecularMachineHasSubstrateAssociation	Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein.	no
GeneToDiseaseAssociation	An association between a gene or gene product and a disease, where variation in the gene is correlated with the disease.	yes
CorrelatedGeneToDiseaseAssociation	An association between a gene (or gene product) and a disease for which the gene is statistically correlated with the disease rather than asserted as causal. Such associations typically derive from GWAS, co-occurrence analyses, or other statistical methods, and are annotated with scores such as a z-score or a diseases confidence score.	no
PredicateMapping	A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place.	no
EntityToFeatureOrVariantQualifiersMixin	Qualifiers for entity to variant associations.	no
EntityToFeatureOrDiseaseQualifiersMixin	Qualifiers for entity to disease or phenotype associations.	no
GeneToPhenotypicFeatureAssociation	An association between a gene or gene product and a phenotypic feature, where variation in the gene is correlated with the phenotypic feature.	yes
CausalGeneToDiseaseAssociation	An association between a gene and a disease where variation in the gene has been shown to have a causal role in the disease.	no
ChemicalEntityToBiologicalProcessAssociation	An association between a chemical entity and a biological process, where the chemical entity has some effect on the biological process.	no
EntityToFeatureOrGeneQualifiersMixin	Qualifiers for entity to gene associations.	no
GeneAffectsChemicalAssociation	Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.)	yes
ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation	A regulatory relationship between two genes	yes

Example values

Slot Name	Value
object_direction_qualifier	increased
object_direction_qualifier	downregulated

LinkML Source

name: object direction qualifier
description: 'Composes with the core concept (+ aspect if provided) to describe a
  change in its direction or degree. This qualifier qualifies the object of an association
  (aka: statement).'
examples:
- value: increased
- value: downregulated
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: direction qualifier
domain: association
alias: object_direction_qualifier
domain_of:
- predicate mapping
- gene to gene association
- chemical entity to biological process association
- chemical gene interaction association
- macromolecular machine has substrate association
- gene regulates gene association
- chemical affects biological entity association
- gene affects chemical association
- entity to feature or disease qualifiers mixin
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
- gene to phenotypic feature association
- gene to disease association
- causal gene to disease association
- correlated gene to disease association
- chemical entity or gene or gene product regulates gene association
range: DirectionQualifierEnum