Slot: object_direction_qualifier

Description: Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement).

Domain: Association
Range: DirectionQualifierEnum

Inheritance

• association_slot
  • qualifier
    • direction_qualifier
      • object_direction_qualifier

Applicable Classes

Name	Description	Modifies Slot
PredicateMapping	A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place.	no
GeneToGeneAssociation	parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction.	no
ChemicalEntityToBiologicalProcessAssociation	An association between a chemical entity and a biological process, where the chemical entity has some effect on the biological process.	no
ChemicalGeneInteractionAssociation	describes an interaction between a chemical entity and a gene or gene product. Any biological or chemical effect resulting from such an interaction are out of scope, and covered by the ChemicalAffectsGeneAssociation type (e.g. impact of a chemical on the abundance, activity, structure, etc, of either participant in the interaction)	yes
MacromolecularMachineHasSubstrateAssociation	Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein.	no
GeneRegulatesGeneAssociation	Describes a regulatory relationship between two genes or gene products.	yes
ChemicalAffectsBiologicalEntityAssociation	Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)	yes
ChemicalGeneSensitivityAssociation	Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation.	yes
GeneAffectsChemicalAssociation	Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.)	yes
EntityToFeatureOrDiseaseQualifiersMixin	Qualifiers for entity to disease or phenotype associations.	no
EntityToFeatureOrVariantQualifiersMixin	Qualifiers for entity to variant associations.	no
EntityToFeatureOrGeneQualifiersMixin	Qualifiers for entity to gene associations.	no
FeatureOrDiseaseQualifiersToEntityMixin	Qualifiers for disease or phenotype to entity associations.	no
GeneToPhenotypicFeatureAssociation	An association between a gene or gene product and a phenotypic feature, where variation in the gene is correlated with the phenotypic feature.	yes
GeneToDiseaseAssociation	An association between a gene or gene product and a disease, where variation in the gene is correlated with the disease.	yes
CausalGeneToDiseaseAssociation	An association between a gene and a disease where variation in the gene has been shown to have a causal role in the disease.	no
CorrelatedGeneToDiseaseAssociation	An association between a gene (or gene product) and a disease for which the gene is statistically correlated with the disease rather than asserted as causal. Such associations typically derive from GWAS, co-occurrence analyses, or other statistical methods, and are annotated with scores such as a z-score or a diseases confidence score.	no
ChemicalEntityOrGeneOrGeneProductRegulatesGeneAssociation	A regulatory relationship between two genes	yes

Example values

Slot Name	Value
object_direction_qualifier	increased
object_direction_qualifier	downregulated

LinkML Source

name: object direction qualifier
description: 'Composes with the core concept (+ aspect if provided) to describe a
  change in its direction or degree. This qualifier qualifies the object of an association
  (aka: statement).'
examples:
- value: increased
- value: downregulated
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: direction qualifier
domain: association
alias: object_direction_qualifier
domain_of:
- predicate mapping
- gene to gene association
- chemical entity to biological process association
- chemical gene interaction association
- macromolecular machine has substrate association
- gene regulates gene association
- chemical affects biological entity association
- chemical gene sensitivity association
- gene affects chemical association
- entity to feature or disease qualifiers mixin
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
- gene to phenotypic feature association
- gene to disease association
- causal gene to disease association
- correlated gene to disease association
- chemical entity or gene or gene product regulates gene association
range: DirectionQualifierEnum