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Class: EntityToPhenotypicFeatureAssociation

Description: An association between any entity and a phenotypic feature, capturing clinical context such as approval status, research phase, regulatory approvals, and number of cases.
classDiagram class EntityToPhenotypicFeatureAssociation EntityToPhenotypicFeatureAssociationMixin <|-- EntityToPhenotypicFeatureAssociation ClinicalTrialAndRegulatoryApprovalContextMixin <|-- EntityToPhenotypicFeatureAssociation Association <|-- EntityToPhenotypicFeatureAssociation EntityToPhenotypicFeatureAssociation : adjusted_p_value EntityToPhenotypicFeatureAssociation : agent_type EntityToPhenotypicFeatureAssociation --|> AgentTypeEnum : agent_type EntityToPhenotypicFeatureAssociation : aggregator_knowledge_source EntityToPhenotypicFeatureAssociation : anatomical_context_qualifier EntityToPhenotypicFeatureAssociation : association_basis_qualifier EntityToPhenotypicFeatureAssociation --|> AssociationBasisEnum : association_basis_qualifier EntityToPhenotypicFeatureAssociation : category EntityToPhenotypicFeatureAssociation : clinical_approval_status EntityToPhenotypicFeatureAssociation --|> ClinicalApprovalStatusEnum : clinical_approval_status EntityToPhenotypicFeatureAssociation : deprecated EntityToPhenotypicFeatureAssociation : description EntityToPhenotypicFeatureAssociation : disease_context_qualifier EntityToPhenotypicFeatureAssociation --|> Disease : disease_context_qualifier EntityToPhenotypicFeatureAssociation : effect_size EntityToPhenotypicFeatureAssociation : effect_type EntityToPhenotypicFeatureAssociation --|> EffectTypeEnum : effect_type EntityToPhenotypicFeatureAssociation : elevate_to_prediction EntityToPhenotypicFeatureAssociation : evidence_count EntityToPhenotypicFeatureAssociation : frequency_qualifier EntityToPhenotypicFeatureAssociation : has_attribute EntityToPhenotypicFeatureAssociation --|> Attribute : has_attribute EntityToPhenotypicFeatureAssociation : has_confidence_score EntityToPhenotypicFeatureAssociation : has_count EntityToPhenotypicFeatureAssociation : has_evidence EntityToPhenotypicFeatureAssociation --|> InformationContentEntity : has_evidence EntityToPhenotypicFeatureAssociation : has_evidence_of_type EntityToPhenotypicFeatureAssociation --|> EvidenceType : has_evidence_of_type EntityToPhenotypicFeatureAssociation : has_percentage EntityToPhenotypicFeatureAssociation : has_quotient EntityToPhenotypicFeatureAssociation : has_supporting_studies EntityToPhenotypicFeatureAssociation --|> Study : has_supporting_studies EntityToPhenotypicFeatureAssociation : has_total EntityToPhenotypicFeatureAssociation : id EntityToPhenotypicFeatureAssociation : iri EntityToPhenotypicFeatureAssociation : knowledge_level EntityToPhenotypicFeatureAssociation --|> KnowledgeLevelEnum : knowledge_level EntityToPhenotypicFeatureAssociation : knowledge_source EntityToPhenotypicFeatureAssociation : max_research_phase EntityToPhenotypicFeatureAssociation --|> ResearchPhaseEnum : max_research_phase EntityToPhenotypicFeatureAssociation : name EntityToPhenotypicFeatureAssociation : negated EntityToPhenotypicFeatureAssociation : number_of_cases EntityToPhenotypicFeatureAssociation : object EntityToPhenotypicFeatureAssociation --|> PhenotypicFeature : object EntityToPhenotypicFeatureAssociation : object_aspect_qualifier EntityToPhenotypicFeatureAssociation --|> GeneOrGeneProductOrChemicalEntityAspectEnum : object_aspect_qualifier EntityToPhenotypicFeatureAssociation : object_category EntityToPhenotypicFeatureAssociation --|> OntologyClass : object_category EntityToPhenotypicFeatureAssociation : object_category_closure EntityToPhenotypicFeatureAssociation --|> OntologyClass : object_category_closure EntityToPhenotypicFeatureAssociation : object_closure EntityToPhenotypicFeatureAssociation : object_direction_qualifier EntityToPhenotypicFeatureAssociation --|> DirectionQualifierEnum : object_direction_qualifier EntityToPhenotypicFeatureAssociation : object_feature_name EntityToPhenotypicFeatureAssociation : object_label_closure EntityToPhenotypicFeatureAssociation : object_namespace EntityToPhenotypicFeatureAssociation : object_specialization_qualifier EntityToPhenotypicFeatureAssociation : original_object EntityToPhenotypicFeatureAssociation : original_predicate EntityToPhenotypicFeatureAssociation : original_subject EntityToPhenotypicFeatureAssociation : p_value EntityToPhenotypicFeatureAssociation : population_context_qualifier EntityToPhenotypicFeatureAssociation --|> PopulationOfIndividualOrganisms : population_context_qualifier EntityToPhenotypicFeatureAssociation : predicate EntityToPhenotypicFeatureAssociation : primary_knowledge_source EntityToPhenotypicFeatureAssociation : publications EntityToPhenotypicFeatureAssociation --|> Publication : publications EntityToPhenotypicFeatureAssociation : qualified_predicate EntityToPhenotypicFeatureAssociation : qualifier EntityToPhenotypicFeatureAssociation : qualifiers EntityToPhenotypicFeatureAssociation --|> OntologyClass : qualifiers EntityToPhenotypicFeatureAssociation : regulatory_approvals EntityToPhenotypicFeatureAssociation : retrieval_source_ids EntityToPhenotypicFeatureAssociation --|> RetrievalSource : retrieval_source_ids EntityToPhenotypicFeatureAssociation : semmed_agreement_count EntityToPhenotypicFeatureAssociation : sex_qualifier EntityToPhenotypicFeatureAssociation --|> BiologicalSex : sex_qualifier EntityToPhenotypicFeatureAssociation : sources EntityToPhenotypicFeatureAssociation --|> RetrievalSource : sources EntityToPhenotypicFeatureAssociation : species_context_qualifier EntityToPhenotypicFeatureAssociation --|> OrganismTaxon : species_context_qualifier EntityToPhenotypicFeatureAssociation : statistical_significance_qualifier EntityToPhenotypicFeatureAssociation --|> StatisticalSignificanceQualifierEnum : statistical_significance_qualifier EntityToPhenotypicFeatureAssociation : stringdb_coexpression_score EntityToPhenotypicFeatureAssociation : stringdb_combined_score EntityToPhenotypicFeatureAssociation : stringdb_experimental_score EntityToPhenotypicFeatureAssociation : subject EntityToPhenotypicFeatureAssociation --|> NamedThing : subject EntityToPhenotypicFeatureAssociation : subject_aspect_qualifier EntityToPhenotypicFeatureAssociation --|> GeneOrGeneProductOrChemicalEntityAspectEnum : subject_aspect_qualifier EntityToPhenotypicFeatureAssociation : subject_category EntityToPhenotypicFeatureAssociation --|> OntologyClass : subject_category EntityToPhenotypicFeatureAssociation : subject_category_closure EntityToPhenotypicFeatureAssociation --|> OntologyClass : subject_category_closure EntityToPhenotypicFeatureAssociation : subject_closure EntityToPhenotypicFeatureAssociation : subject_direction_qualifier EntityToPhenotypicFeatureAssociation --|> DirectionQualifierEnum : subject_direction_qualifier EntityToPhenotypicFeatureAssociation : subject_feature_name EntityToPhenotypicFeatureAssociation : subject_label_closure EntityToPhenotypicFeatureAssociation : subject_namespace EntityToPhenotypicFeatureAssociation : subject_specialization_qualifier EntityToPhenotypicFeatureAssociation : supporting_text EntityToPhenotypicFeatureAssociation : timepoint EntityToPhenotypicFeatureAssociation : type EntityToPhenotypicFeatureAssociation : update_date

Inheritance

Slots

Name Cardinality and Range Inheritance Examples
sex_qualifier:
a qualifier used in a phenotypic association to state whether the association is specific to a particular sex. 		0..1
BiologicalSex		 EntityToPhenotypicFeatureAssociationMixin
clinical_approval_status:
The clinical approval status of a chemical entity for treating a specific disease or condition, as captured in the context of the association between the chemical and the disease. 		0..1
ClinicalApprovalStatusEnum		 ClinicalTrialAndRegulatoryApprovalContextMixin
max_research_phase:
The maximum research phase reached for a specific chemical-disease pair, indicating the highest clinical trial phase achieved for the chemical entity's investigation as a treatment for the associated disease or condition. 		0..1
ResearchPhaseEnum		 ClinicalTrialAndRegulatoryApprovalContextMixin
regulatory_approvals:
Numbers or identifiers issued by regulatory agencies that identify specific drug applications or marketing authorizations. Values are application-number provenance and are not guaranteed to be verified identifiers from any particular agency; they may include FDA application numbers (for example, as seen with ranitidine having both ANADA200536 and ANDA200536) as well as identifiers from other regulatory agencies such as EMA marketing authorizations. Each drug can have multiple approval numbers. 		*
String		 ClinicalTrialAndRegulatoryApprovalContextMixin
number_of_cases:
The number of cases in a study or clinical trial, primarily used in conversion of drug approval data. 		0..1
Integer		 ClinicalTrialAndRegulatoryApprovalContextMixin
subject:
connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
NamedThing		 FrequencyQualifierMixin, Association
predicate:
Has a value from the Biolink 'related_to' hierarchy. In RDF, this corresponds to rdf:predicate and in Neo4j this corresponds to the relationship type. The convention is for an edge label in snake_case form. For example, biolink:related_to, biolink:causes, biolink:treats 		1
Uriorcurie		 FrequencyQualifierMixin, Association
object:
disease or phenotype 		1
PhenotypicFeature		 FrequencyQualifierMixin, Association HP:0002487, WBPhenotype:0000180, MP:0001569
negated:
if set to true, then the association is negated i.e. is not true 		0..1
Boolean		 Association
qualifier:
grouping slot for all qualifiers on an edge. useful for testing compliance with association classes 		0..1
String		 Association
qualifiers:
connects an association to qualifiers that modify or qualify the meaning of that association 		*
OntologyClass		 Association
publications:
One or more publications that report the statement expressed in an Association, or provide information used as evidence supporting this statement. 		*
Publication		 Association
sources:
A set of RetrievalSources, which traces where the statement expressed in an Association came from. For example, the provenance of a Gene-Chemical Edge might be traced through the Translator Resource that provided it (e.g. MolePro) to one or more intermediate aggregator resources (e.g. ChEMBL), and finally to the resource that originally created/curated it (e.g. ClinicalTrials.org). 		*
RetrievalSource		 Association
has_evidence_of_type:
Connects an association to an evidence type ontology term. Generally represents terms from the ECO ontology. 		*
EvidenceType		 Association
has_evidence:
Connects an association to detailed information providing supporting evidence. 		*
InformationContentEntity		 Association
knowledge_source:
An Information Resource from which the knowledge expressed in an Association was retrieved, directly or indirectly. This can be any resource through which the knowledge passed on its way to its currently serialized form. In practice, implementers should use one of the more specific subtypes of this generic property. 		0..1
String		 Association
primary_knowledge_source:
The most upstream source of the knowledge expressed in an Association that an implementer can identify. Performing a rigorous analysis of upstream data providers is expected; every effort is made to catalog the most upstream source of data in this property. Only one data source should be declared primary in any association. "aggregator knowledge source" can be used to capture non-primary sources. 		0..1
String		 Association
aggregator_knowledge_source:
An intermediate aggregator resource from which knowledge expressed in an Association was retrieved downstream of the original source, on its path to its current serialized form. 		*
String		 Association
knowledge_level:
Describes the level of knowledge expressed in a statement, based on the reasoning or analysis methods used to generate the statement, or the scope or specificity of what the statement expresses to be true. 		1
KnowledgeLevelEnum		 Association knowledge_assertion, prediction, statistical_association
agent_type:
Describes the high-level category of agent who originally generated a statement of knowledge or other type of information. 		1
AgentTypeEnum		 Association manual_agent, automated_agent, computational_model, text_mining_agent
timepoint:
a point in time 		0..1
TimeType		 Association
original_subject:
used to hold the original subject of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
String		 Association
original_predicate:
used to hold the original relation/predicate that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
Uriorcurie		 Association
original_object:
used to hold the original object of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
String		 Association
subject_feature_name:
Used to describe a subordinate feature of the associated subject for example, a particular sequence variant of a gene 		0..1
String		 Association
object_feature_name:
Used to describe a subordinate feature of the associated object for example, a symptom diagnosis of a disease 		0..1
String		 Association
subject_category:
Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
OntologyClass		 Association biolink:Gene
object_category:
Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
OntologyClass		 Association biolink:Disease
subject_closure:
Used to hold the subject closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association
object_closure:
Used to hold the object closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association ['MONDO:0000167', 'MONDO:0005395']
subject_category_closure:
Used to hold the subject category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
OntologyClass		 Association ['biolink:Gene', 'biolink:NamedThing']
object_category_closure:
Used to hold the object category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
OntologyClass		 Association ['biolink:Disease', 'biolink:NamedThing']
subject_namespace:
Used to hold the subject namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
String		 Association NCBIGene
object_namespace:
Used to hold the object namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
String		 Association MONDO
subject_label_closure:
Used to hold the subject label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association ['BRCA1']
object_label_closure:
Used to hold the object label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association breast cancer, cancer
retrieval_source_ids:
A list of retrieval sources that served as a source of knowledge expressed in an Edge, or a source of data used to generate this knowledge. 		*
RetrievalSource		 Association
p_value:
A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone. 		0..1
Float		 Association
adjusted_p_value:
The adjusted p-value is the probability of obtaining test results at least as extreme as the results actually observed, under the assumption that the null hypothesis is correct, adjusted for multiple comparisons. P is always italicized and capitalized. The actual P value* should be expressed (P=. 04) rather than expressing a statement of inequality (P<. 05), unless P<. 		0..1
Float		 Association
statistical_significance_qualifier:
A statement qualifier that categorizes an association's evidence by statistical significance into coarse bands, as a categorical companion to the numeric 'p value' and 'adjusted p value' slots. It applies only to assessments derived from a quantitative significance statistic (raw p-value, multiple-testing-adjusted p-value, or q-value/FDR), and MUST NOT encode ordinal study-stage, evidence-tier, or confidence-level labels (e.g. clinical trial phases) that are not statistical-significance statements. 		0..1
StatisticalSignificanceQualifierEnum		 Association very_strongly_significant, strongly_significant, significant, suggestive, not_significant
effect_size:
A quantitative measure of the magnitude and direction of an effect or association between the subject and object of an edge, as estimated by a statistical method. The specific metric used (e.g. Cohen's d, odds ratio, Pearson's r) is indicated by the companion 'effect type' slot. 		0..1
Float		 Association
effect_type:
Specifies the statistical metric or method used to compute the numeric value in the companion 'effect size' slot. This disambiguates the effect size value, which is otherwise uninterpretable without knowing the metric (e.g. Cohen's d vs. odds ratio vs. Pearson's r). 		0..1
EffectTypeEnum		 Association cohens_d, odds_ratio, pearsons_r
supporting_text:
The segment of text from a document that supports the mined assertion. 		*
String		 Association Here, we report two new cases of rivaroxaban-induced hepatitis.
has_supporting_studies:
Studies that produced information used as evidence to generate the knowledge expressed in an Association. 		*
Study		 Association
update_date:
date on which an entity was updated. This can be applied to nodes or edges 		0..1
Date		 Association
has_confidence_score:
connects an association to a quantitative (numeric) value that can be interpreted as an indicator of the degree of confidence that a piece of information is true, and accurately reflects the aspect of reality it is about. 		0..1
Float		 Association
stringdb_combined_score:
A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated, based on the probabilistic integration of all available evidence channels (e.g., curated databases, experiments, co-expression, evolutionary evidence, and text mining). Higher scores indicate greater confidence in the existence of a biologically meaningful functional association. 		0..1
Float		 Association
stringdb_experimental_score:
A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated based solely on experimental evidence, including laboratory measurements of physical interactions or protein associations. Higher scores indicate stronger experimental support for a biological association between the proteins. 		0..1
Float		 Association
stringdb_coexpression_score:
A confidence score assigned by STRING representing the estimated likelihood that two proteins are functionally associated based solely on evidence that their encoding genes exhibit correlated expression patterns across one or more transcriptomic datasets. Higher scores indicate stronger support for a biological association inferred from gene co-expression. 		0..1
Float		 Association
elevate_to_prediction:
A boolean flag indicating whether a clinical trial finding should be elevated to a prediction. 		0..1
Boolean		 Association
evidence_count:
The number of evidence instances that are connected to an association. 		0..1
Integer		 Association
semmed_agreement_count:
The number of times this concept has been asserted in the SemMedDB literature database. 		0..1
Integer		 Association
association_basis_qualifier:
A statement-level qualifier used with the 'associated with' predicate (or one of its subpredicates) to indicate the biological, clinical, or statistical basis of the asserted association. Use this qualifier when no more specific predicate exists to capture the intended meaning of the association. 		0..1
AssociationBasisEnum		 Association
species_context_qualifier:
A statement qualifier representing a taxonomic category of species in which a relationship expressed in an association took place. 		0..1
OrganismTaxon		 Association NCBITaxon:7955, NCBITaxon:9606
id:
A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI 		1
String		 Entity
iri:
An IRI for an entity. This is determined by the id using expansion rules. 		0..1
IriType		 Entity
category:
Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag. In an RDF database it should be a biolink model class URI. This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values biolink:Protein, biolink:GeneProduct, biolink:MolecularEntity. In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature f may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing} 		*
Uriorcurie		 Entity
type:
rdf:type of biolink:Association should be fixed at rdf:Statement 		*
String		 Entity
name:
A human-readable name for an attribute or entity. 		0..1
LabelType		 Entity
description:
a human-readable description of an entity 		0..1
NarrativeText		 Entity
has_attribute:
connects any entity to an attribute 		*
Attribute		 Entity
deprecated:
A boolean flag indicating that an entity is no longer considered current or valid. 		0..1
Boolean		 Entity
has_count:
number of things with a particular property 		0..1
Integer		 FrequencyQuantifier
has_total:
total number of things in a particular reference set 		0..1
Integer		 FrequencyQuantifier
has_quotient:
None 		0..1
Double		 FrequencyQuantifier
has_percentage:
equivalent to has quotient multiplied by 100 		0..1
Double		 FrequencyQuantifier
subject_aspect_qualifier:
Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept. The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association. This qualifier specifies a change in the subject of an association (aka: statement). 		0..1
GeneOrGeneProductOrChemicalEntityAspectEnum		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin stability, abundance, expression, exposure
subject_direction_qualifier:
Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement). 		0..1
DirectionQualifierEnum		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin increased, downregulated
object_aspect_qualifier:
Composes with the core concept to describe new concepts of a different ontological type. e.g. a process in which the core concept participates, a function/activity/role held by the core concept, or a characteristic/quality that inheres in the core concept. The purpose of the aspect slot is to indicate what aspect is being affected in an 'affects' association. This qualifier specifies a change in the object of an association (aka: statement). 		0..1
GeneOrGeneProductOrChemicalEntityAspectEnum		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin stability, abundance, expression, exposure
object_direction_qualifier:
Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement). 		0..1
DirectionQualifierEnum		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin increased, downregulated
qualified_predicate:
Predicate to be used in an association when subject and object qualifiers are present and the full reading of the statement requires a qualification to the predicate in use in order to refine or increase the specificity of the full statement reading. Has a value from the Biolink 'related_to' hierarchy, for example, biolink:related_to, biolink:causes, biolink:treats This qualifier holds a relationship to be used instead of that expressed by the primary predicate, in a ‘full statement’ reading of the association, where qualifier-based semantics are included. This is necessary only in cases where the primary predicate does not work in a full statement reading. 		0..1
Uriorcurie		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin biolink:causes
disease_context_qualifier:
A context qualifier representing a disease or condition in which a relationship expressed in an association took place. 		0..1
Disease		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin MONDO:0004979, MONDO:0005148
subject_specialization_qualifier:
A qualifier that composes with a core subject/object concept to define a more specific version of the subject concept, specifically using an ontology term that is not a subclass or descendant of the core concept and in the vast majority of cases, is of a different ontological namespace than the category or namespace of the subject identifier. 		0..1
Uriorcurie		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin
object_specialization_qualifier:
A qualifier that composes with a core subject/object concept to define a more specific version of the subject concept, specifically using an ontology term that is not a subclass or descendant of the core concept and in the vast majority of cases, is of a different ontological namespace than the category or namespace of the subject identifier. 		0..1
Uriorcurie		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin
anatomical_context_qualifier:
A statement qualifier representing an anatomical location where an relationship expressed in an association took place (can be a tissue, cell type, or sub-cellular location). 		*
String		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin UBERON:0000178, UBERON:0000956, GO:0005794
population_context_qualifier:
a biological population (general, study, cohort, etc.) with a specific set of characteristics to constrain an association. 		0..1
PopulationOfIndividualOrganisms		 EntityToDiseaseOrPhenotypicFeatureAssociationMixin
frequency_qualifier:
a qualifier used in a phenotypic association to state how frequent the phenotype is observed in the subject 		0..1
FrequencyValue		 FrequencyQualifierMixin

Example values

Slot Name Value
EntityToPhenotypicFeatureAssociation None
EntityToPhenotypicFeatureAssociation None
EntityToPhenotypicFeatureAssociation None

LinkML Source

name: entity to phenotypic feature association
description: An association between any entity and a phenotypic feature, capturing
  clinical context such as approval status, research phase, regulatory approvals,
  and number of cases.
examples:
- object:
    subject: GTOPDB:13663
    predicate: biolink:in_clinical_trials_for
    object: NCIT:C146753
    category: biolink:EntityToPhenotypicFeatureAssociation
    knowledge_level: knowledge_assertion
    agent_type: manual_agent
- object:
    subject: CHEBI:6339
    predicate: biolink:treats
    object: HP:0001822
    category: biolink:EntityToPhenotypicFeatureAssociation
    knowledge_level: knowledge_assertion
    agent_type: manual_agent
- object:
    subject: RXCUI:617430
    predicate: biolink:contraindicated_in
    object: HP:0001410
    category: biolink:EntityToPhenotypicFeatureAssociation
    knowledge_level: knowledge_assertion
    agent_type: manual_validation_of_automated_agent
    publications:
    - 2970fe7e-9e1f-47aa-85ad-663ee15c7e06
    - a5fa252a-d39e-4099-a230-b665fbb97a80
    - b897c800-24a2-4e76-8668-498c5515c3d0
    - babf3b8d-f2ce-407d-9407-728c45eb19ee
    - d74e93e5-11c9-434e-a60c-4a4f911dd0f8
from_schema: https://w3id.org/biolink/vocab/
is_a: association
mixins:
- entity to phenotypic feature association mixin
- clinical trial and regulatory approval context mixin
defining_slots:
- subject
- object