Slot: subject_direction_qualifier

Description: Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the subject of an association (aka: statement).

Domain: Association
Range: DirectionQualifierEnum

Inheritance

• association_slot
  • qualifier
    • direction_qualifier
      • subject_direction_qualifier

Applicable Classes

Name	Description	Modifies Slot
PredicateMapping	A deprecated predicate mapping object contains the deprecated predicate and an example of the rewiring that should be done to use a qualified statement in its place.	no
GeneToGeneAssociation	parent class for different kinds of gene-gene or gene product to gene product relationships. Includes homology and interaction.	no
MacromolecularMachineHasSubstrateAssociation	Describes the relationship between an enzyme (usually a macromolecular complex or gene product) and the molecules it acts on (substrate). The substrate can be a chemical, a polypeptide, or a protein.	no
ChemicalAffectsBiologicalEntityAssociation	Describes an effect that a chemical has on a biological entity (e.g. an impact of on its abundance, activity,localization, processing, expression, etc.)	yes
ChemicalGeneSensitivityAssociation	Describes a relationship in which a chemical entity affects the sensitivity or susceptibility of a biological system to a gene or gene product (e.g. a chemical that increases or decreases the response to a gene or gene product). This covers 'response to substance' style interactions from sources such as CTD that map to the 'affects sensitivity to' predicate hierarchy, as opposed to the abundance/activity/processing effects covered by ChemicalAffectsGeneAssociation.	yes
GeneAffectsChemicalAssociation	Describes an effect that a gene or gene product has on a chemical entity (e.g. an impact of on its abundance, activity, localization, processing, transport, etc.)	yes
EntityToFeatureOrVariantQualifiersMixin	Qualifiers for entity to variant associations.	no
EntityToFeatureOrGeneQualifiersMixin	Qualifiers for entity to gene associations.	no
FeatureOrDiseaseQualifiersToEntityMixin	Qualifiers for disease or phenotype to entity associations.	no
EntityToDiseaseOrPhenotypicFeatureAssociationMixin	A mixin applied to any association whose object (target node) is a disease or a phenotypic feature. Provides the shared qualifier vocabulary for such statements; subtypes narrow the object range to a disease or to a phenotypic feature specifically.	no

Example values

Slot Name	Value
subject_direction_qualifier	increased
subject_direction_qualifier	downregulated

LinkML Source

name: subject direction qualifier
description: 'Composes with the core concept (+ aspect if provided) to describe a
  change in its direction or degree. This qualifier qualifies the subject of an association
  (aka: statement).'
examples:
- value: increased
- value: downregulated
in_subset:
- translator_minimal
from_schema: https://w3id.org/biolink/vocab/
is_a: direction qualifier
domain: association
alias: subject_direction_qualifier
domain_of:
- predicate mapping
- gene to gene association
- macromolecular machine has substrate association
- chemical affects biological entity association
- chemical gene sensitivity association
- gene affects chemical association
- entity to feature or variant qualifiers mixin
- entity to feature or gene qualifiers mixin
- feature or disease qualifiers to entity mixin
- entity to disease or phenotypic feature association mixin
range: DirectionQualifierEnum