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Slot: allelic_requirement

Description: The allele configuration of a particular gene or variant required for the expression of a disease or phenotype in a specific patient or instance.

Domain: Association
Range: String

Inheritance

Applicable Classes

Name Description Modifies Slot
GeneToPhenotypicFeatureAssociation An association between a gene or gene product and a phenotypic feature, where variation in the gene is correlated with the phenotypic feature. no
GeneToDiseaseAssociation An association between a gene or gene product and a disease, where variation in the gene is correlated with the disease. no
CausalGeneToDiseaseAssociation An association between a gene and a disease where variation in the gene has been shown to have a causal role in the disease. no
CorrelatedGeneToDiseaseAssociation An association between a gene (or gene product) and a disease for which the gene is statistically correlated with the disease rather than asserted as causal. Such associations typically derive from GWAS, co-occurrence analyses, or other statistical methods, and are annotated with scores such as a z-score or a diseases confidence score. no

LinkML Source

name: allelic requirement
description: The allele configuration of a particular gene or variant required for
  the expression of a disease or phenotype in a specific patient or instance.
comments:
- This edge property may be used by associations between Genes or SequenceVariants
  and DiseaseOrPhenotypicFeatures to provide the inheritance pattern and genetic context
  of the relationship. Terms from the HP mode of inheritance sub-ontology (HP:0000005)
  should be used in the value of this slot. This slot differs from the predicate "has_mode_of_inheritance",
  in that the predicate is used to link a disease or phenotype with its general inheritance
  pattern (how it is typically transmitted from one generation to the next, regardless
  of the specific genetic variant that is present in an individual or instance).
from_schema: https://w3id.org/biolink/vocab/
is_a: association slot
domain: association
alias: allelic_requirement
domain_of:
- gene to phenotypic feature association
- gene to disease association
- causal gene to disease association
- correlated gene to disease association
range: string
pattern: ^HP:\d{7}$