Enum: DruggableGeneCategoryEnum

An enumeration of druggability categories for gene targets as defined by the IDG (Illuminating the Druggable Genome) / Pharos target development level classification: Tclin (targets of approved drugs), Tchem (targets with potent bioactives), Tbio (targets with biological knowledge), and Tdark (poorly characterized targets).

Permissible Values

Value	Meaning	Description
tclin	None	These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
tbio	None	These targets have activities in ChEMBL, Guide to Pharmacology or DrugCentral that satisfy the activity thresholds detailed below.
tchem	None	These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: target is above the cutoff criteria for the target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code
tdark	None	These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: A PubMed text-mining score from Jensen Lab less than 5, greater than or equal TO 3 Gene RIFs, or less than or equal to 50 Antibodies available according to http://antibodypedia.com.

Slots constrained by this enum

Name
druggable_gene_category

LinkML Source

name: DruggableGeneCategoryEnum
description: 'An enumeration of druggability categories for gene targets as defined
  by the IDG (Illuminating the Druggable Genome) / Pharos target development level
  classification: Tclin (targets of approved drugs), Tchem (targets with potent bioactives),
  Tbio (targets with biological knowledge), and Tdark (poorly characterized targets).'
from_schema: https://w3id.org/biolink/vocab/
permissible_values:
  tclin:
    text: tclin
    description: These targets have activities in DrugCentral (ie. approved drugs)
      with known mechanism of action.
  tbio:
    text: tbio
    description: These targets have activities in ChEMBL, Guide to Pharmacology or
      DrugCentral that satisfy the activity thresholds detailed below.
  tchem:
    text: tchem
    description: 'These targets do not have known drug or small molecule activities
      that satisfy the activity thresholds detailed below AND satisfy one or more
      of the following criteria: target is above the cutoff criteria for the target
      is annotated with a Gene Ontology Molecular Function or Biological Process leaf
      term(s) with an Experimental Evidence code'
  tdark:
    text: tdark
    description: 'These are targets about which virtually nothing is known. They do
      not have known drug or small molecule activities that satisfy the activity thresholds
      detailed below AND satisfy two or more of the following criteria: A PubMed text-mining
      score from Jensen Lab less than 5, greater than or equal TO 3 Gene RIFs, or
      less than or equal to 50 Antibodies available according to http://antibodypedia.com.'