Enum: CausalMechanismQualifierEnum

Permissible Values

Value	Meaning	Description
binding	None	A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction.
inhibition	None	A causal mechanism in which the effector binds to the target and negatively effects its normal function, e.g. prevention of enzymatic reaction or activation of downstream pathway.
antibody_inhibition	None	A causal mechanism in which an antibody specifically binds to and interferes with the target.
antagonism	None	A causal mechanism in which the effector binds to a receptor and prevents activation by an agonist through competing for the binding site.
molecular_channel_blockage	None	A causal mechanism in which the effector binds to a molecular channel and prevents or reduces transport of ions through it.
inverse_agonism	None	A causal mechanism in which the effector binds to the same receptor-binding site as an agonist and antagonizes its effects, often exerting the opposite effect of the agonist by suppressing spontaneous receptor signaling.
negative_allosteric_modulation	None	A causal mechanism in which the effector reduces or prevents the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition)
agonism	None	A causal mechanism in which the effector binds and activates a receptor to mimic the effect of an endogenous ligand.
molecular_channel_opening	None	A causal mechanism in which the effector binds to a molecular channel and facilitates transport of ions through it.
positive_allosteric_modulation	None	A causal mechanism in which the effector enhances the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition)
potentiation	None	A causal mechanism in which the effector binds to and enhances or intensifies the effect of some other chemical or drug on its target.
activation	None	A causal mechanism in which the effector binds to and positively affects the normal functioning of its target.
inducer	None	A causal mechanism in which the effector binds to and increases the activity/rate of an enzyme that processes drugs in the body.
transcriptional_regulation	None	A causal mechanism mediated by through the control of target gene transcription
signaling_mediated_control	None	A causal mechanism mediated by the activation or control of signaling events that influence the some aspect of the target entity (e.g. its activity, processing, transport, etc)
stabilization	None	None
stimulation	None	None
releasing_activity	None	None

Slots constrained by this enum

Name
causal_mechanism_qualifier
causal_mechanism_qualifier

LinkML Source

name: CausalMechanismQualifierEnum
from_schema: https://w3id.org/biolink/biolink-model
permissible_values:
  binding:
    text: binding
    description: A causal mechanism mediated by the direct contact between effector
      and target chemical or biomolecular entity, which form a stable physical interaction.
  inhibition:
    text: inhibition
    description: A causal mechanism in which the effector binds to the target and
      negatively effects its normal function, e.g. prevention of enzymatic reaction
      or activation of downstream pathway.
    is_a: binding
    close_mappings:
    - DGIdb:inhibitor
    - SEMMEDDB:INHIBITS
    narrow_mappings:
    - DGIdb:blocker
    - DGIdb:channel_blocker
    - DGIdb:gating_inhibitor
    - CHEMBL.MECHANISM:antisense_inhibitor
    - CHEMBL.MECHANISM:blocker
    - CHEMBL.MECHANISM:inhibitor
    - CHEMBL.MECHANISM:negative_allosteric_modulator
    - CHEMBL.MECHANISM:negative_modulator
    - DGIdb:negative_modulator
  antibody_inhibition:
    text: antibody_inhibition
    description: A causal mechanism in which an antibody specifically binds to and
      interferes with the target.
    is_a: inhibition
  antagonism:
    text: antagonism
    description: A causal mechanism in which the effector binds to a receptor and
      prevents activation by an agonist through competing for the binding site.
    is_a: inhibition
    close_mappings:
    - DGIdb:antagonist
    - CHEMBL.MECHANISM:antagonist
    narrow_mappings:
    - CHEMBL.MECHANISM:allosteric_antagonist
  molecular_channel_blockage:
    text: molecular_channel_blockage
    description: A causal mechanism in which the effector binds to a molecular channel
      and prevents or reduces transport of ions through it.
    is_a: inhibition
  inverse_agonism:
    text: inverse_agonism
    description: A causal mechanism in which the effector binds to the same receptor-binding
      site as an agonist and antagonizes its effects, often exerting the opposite
      effect of the agonist by suppressing spontaneous receptor signaling.
    is_a: inhibition
    close_mappings:
    - CHEMBL.MECHANISM:inverse_agonist
    - DGIdb:inverse_agonist
  negative_allosteric_modulation:
    text: negative_allosteric_modulation
    description: A causal mechanism in which the effector reduces or prevents the
      action of the endogenous ligand of a receptor by binding to a site distinct
      from that ligand (i.e. non-competitive inhibition)
    is_a: inhibition
    close_mappings:
    - CHEMBL.MECHANISM:negative_allosteric_modulator
    - DGIdb:inhibitory_allosteric_modulator
    narrow_mappings:
    - DGIdb:negative_modulator
  agonism:
    text: agonism
    description: A causal mechanism in which the effector binds and activates a receptor
      to mimic the effect of an endogenous ligand.
    is_a: activation
    close_mappings:
    - CHEMBL.MECHANISM:agonist
    - DGIdb:agonist
    narrow_mappings:
    - CHEMBL.MECHANISM:partial_agonist
    - DGIdb:partial_agonist
  molecular_channel_opening:
    text: molecular_channel_opening
    description: A causal mechanism in which the effector binds to a molecular channel
      and facilitates transport of ions through it.
    is_a: activation
    close_mappings:
    - CHEMBL.MECHANISM:opener
  positive_allosteric_modulation:
    text: positive_allosteric_modulation
    description: A causal mechanism in which the effector enhances the action of the
      endogenous ligand of a receptor by binding to a site distinct from that ligand
      (i.e. non-competitive inhibition)
    is_a: activation
    close_mappings:
    - CHEMBL.MECHANISM:positive_allosteric_modulator
    - CHEMBL.MECHANISM:positive_modulator
    - DGIdb:positive_allosteric_modulator
    broad_mappings:
    - DGIdb:modulator
    - DGIdb:allosteric_modulator
  potentiation:
    text: potentiation
    description: A causal mechanism in which the effector  binds to and enhances or
      intensifies the effect of some other chemical or drug on its target.
    is_a: binding
  activation:
    text: activation
    description: A causal mechanism in which the effector binds to and positively
      affects the normal functioning of its target.
    is_a: binding
    close_mappings:
    - CHEMBL.MECHANISM:activator
    - DGIdb:activator
  inducer:
    text: inducer
    description: A causal mechanism in which the effector binds to and increases the
      activity/rate of an enzyme that processes drugs in the body.
    is_a: binding
    close_mappings:
    - DGIdb:inducer
  transcriptional_regulation:
    text: transcriptional_regulation
    description: A causal mechanism mediated by through the control of target gene
      transcription
  signaling_mediated_control:
    text: signaling_mediated_control
    description: A causal mechanism mediated by the activation or control of signaling
      events that influence the some aspect of the target entity (e.g. its activity,
      processing, transport, etc)
  stabilization:
    text: stabilization
    is_a: activation
    close_mappings:
    - CHEMBL.MECHANISM:stabiliser
  stimulation:
    text: stimulation
    is_a: activation
    close_mappings:
    - DGIdb:stimulator
    - SEMMEDDB:STIMULATES
    - DGIdb:stimulator
  releasing_activity:
    text: releasing_activity
    is_a: activation
    close_mappings:
    - CHEMBL:MECHANISM:releasing_agent