Enum: AffinityParameterEnum

The types of parameters that can be used to describe the affinity between two entities, characteristically chemicals and proteins. The values are generally stated as the negative base 10 logarithm of the raw measurements.

Permissible Values

Value	Meaning	Description
pIC50	None	Negative base 10 logarithm of the the inhibitory concentration 50% (IC50) measures the concentration needed to block or inhibit a biological response.
pEC50	None	Negative base 10 logarithm of the molar concentration of a chemical that produces a 50% excitation of a function
pAC50	None	None
pXC50	None	None
pKi	None	Negative base 10 logarithm of the equilibrium binding affinity for a ligand that reduces the activity of its binding partner. Ki represents the concentration at which the inhibitor ligand occupies 50% of the receptor sites when no competing ligand is present
pKon	None	Negative base 10 logarithm of the association rate constant (Kon) describes the rate at which molecules bind to each other.
pKoff	None	Negative base 10 logarithm of the dissociation rate constant (koff) describes the rate at which they dissociate.
pKd	None	Negative base 10 logarithm of the equilibrium dissociation constant (KD) which is a measure of the binding affinity and is defined as the ratio of koff to kon.

Slots constrained by this enum

Name
affinity_parameter

LinkML Source

name: AffinityParameterEnum
description: The types of parameters that can be used to describe the affinity between
  two entities, characteristically chemicals and proteins. The values are generally
  stated as the negative base 10 logarithm of the raw measurements.
from_schema: https://w3id.org/biolink/vocab/
permissible_values:
  pIC50:
    text: pIC50
    description: Negative base 10 logarithm of the the inhibitory concentration 50%
      (IC50) measures the concentration needed to block or inhibit a biological response.
  pEC50:
    text: pEC50
    description: Negative base 10 logarithm of the molar concentration of a chemical
      that produces a 50% excitation of a function
  pAC50:
    text: pAC50
  pXC50:
    text: pXC50
  pKi:
    text: pKi
    description: Negative base 10 logarithm of the equilibrium binding affinity for
      a ligand that reduces the activity of its binding partner. Ki represents the
      concentration at which the inhibitor ligand occupies 50% of the receptor sites
      when no competing ligand is present
  pKon:
    text: pKon
    description: Negative base 10 logarithm of the association rate constant (Kon)
      describes the rate at which molecules bind to each other.
  pKoff:
    text: pKoff
    description: Negative base 10 logarithm of the dissociation rate constant (koff)
      describes the rate at which they dissociate.
  pKd:
    text: pKd
    description: Negative base 10 logarithm of the equilibrium dissociation constant
      (KD) which is a measure of the binding affinity and is defined as the ratio
      of koff to kon.