Clinical Trials Knowledge Provider (CTKP) Reference Ingest Guide
Source Information
InfoRes ID: infores:aact
Description: Aggregate Analysis of ClinicalTrial.gov (AACT) - supporting data source for CTKP
Terms of Use: Not specified
Additional Notes: CTKP processes data from AACT which is derived from researcher submissions to clinicaltrials.gov
Ingest Information
Ingest Categories: primary_knowledge_provider
Utility: CTKP provides an improved version of clinical trials information that addresses quality and computability issues with sources it uses (AACT, ct.gov), as well as treatment assertions derived from this data. This type of knowledge is critical for many Translator query types.
Scope: Clinical trials information including interventions, diseases/conditions, and treatment assertions derived from clinical trial outcomes.
Relevant Files
| File Name | Location | Description |
|---|---|---|
| CTKP processed data | https://ctkp.ncats.io/ | Clinical trials data processed from AACT/clinicaltrials.gov |
Included Content
| File Name | Included Records | Fields Used |
|---|---|---|
| CTKP processed data | Clinical trial interventions and their associated diseases/conditions, plus treatment assertions for successful trials | NCT Identifier, interventions, diseases/conditions, adverse events, trial phases |
Target Information
Target InfoRes ID: infores:ctkp
Edge Types
| Subject Categories | Predicate | Object Categories | Knowledge Level | Agent Type | UI Explanation |
|---|---|---|---|---|---|
| biolink:ChemicalEntity, biolink:MolecularMixture | biolink:in_clinical_trials_for | biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | manual_agent | The in_clinical_trials_for predicate reports that an intervention was tested in a clinical trial for a particular disease - based on a registered trial in ct.gov. |
| biolink:ChemicalEntity, biolink:MolecularMixture | biolink:treats | biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | manual_agent | The treats predicate reports that an intervention was shown to successfully treat a particular disease in virtue of its passing Phase 3 or being interrogated in a Phase 4 trial. |
Node Types
| Node Category | Source Identifier Types | Additional Notes |
|---|---|---|
| biolink:ChemicalEntity | Not specified | |
| biolink:MolecularMixture | Not specified | |
| biolink:SmallMolecule | Not specified | |
| biolink:DiseaseOrPhenotypicFeature | Not specified |
Provenance Information
Contributors: - Gwenlyn Glusman - code author, domain expertise - Matthew Brush - data modeling