Slot: regulates (multivalued)
Description: A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation. Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction.
Notes: The RO definition of 'directly regulates the activity of' is an exact_mapping here because it describes genetic regulation from the point of view of one genetic entity regulating another, as opposed to "RO:0002211" which describes process to process regulation.
Notes: The RO definition of 'directly regulates the activity of' is an exact_mapping here because it describes genetic regulation from the point of view of one genetic entity regulating another, as opposed to "RO:0002211" which describes process to process regulation.
Domain: PhysicalEssenceOrOccurrent
Range: PhysicalEssenceOrOccurrent
Inheritance
- related_to
- related_to_at_instance_level
- affects
- regulates [ interacts_with]
- affects
- related_to_at_instance_level
Annotations
| property | value |
|---|---|
| canonical_predicate | True |
LinkML Source
name: regulates
annotations:
canonical_predicate:
tag: canonical_predicate
value: true
description: A more specific form of affects, that implies the effect results from
a biologically evolved control mechanism. Gene-affects-gene relationships will (almost)
always involve regulation. Exogenous/environmental chemical-affects-gene relationships
are not cases of regulation in this definition. Instead these would be captured
using the 'affects' predicate, or possibly one of the 'interacts with' predicates
depending on the nature of the interaction.
notes:
- The RO definition of 'directly regulates the activity of' is an exact_mapping here
because it describes genetic regulation from the point of view of one genetic entity
regulating another, as opposed to "RO:0002211" which describes process to process
regulation.
from_schema: https://w3id.org/biolink/biolink-model
exact_mappings:
- RO:0002448
broad_mappings:
- WIKIDATA_PROPERTY:P128
- CHEMBL.MECHANISM:modulator
- RO:0002295
- RO:0002332
- RO:0002448
is_a: affects
mixins:
- interacts with
domain: physical essence or occurrent
inherited: true
alias: regulates
range: physical essence or occurrent
multivalued: true