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Class: causal_mechanism_qualifier_enum

URI: biolink:causal_mechanism_qualifier_enum

Other properties

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Permissible Values

Text Description Meaning Other Information
binding A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction.    
inhibition A causal mechanism in which the effector binds to the target and negatively effects its normal function, e.g. prevention of enzymatic reaction or activation of downstream pathway.   {‘is_a’: ‘binding’}
antibody inhibition A causal mechanism in which an antibody specifically binds to and interferes with the target.   {‘is_a’: ‘inhibition’}
antagonism A causal mecahnism in which the effector binds to a receptor and prevents activation by an agonist through competing for the binding site.   {‘is_a’: ‘inhibition’}
molecular channel blockage A causal mechanism in which the effector binds to a molecular channel and prevents or reduces transport of ions through it.   {‘is_a’: ‘inhibition’}
inverse agonism A causal mechanism in which the effector binds to the same receptor-binding site as an agonist and antagonizes its effects, often exerting the opposite effect of the agonist by suppressing spontaneous receptor signaling.   {‘is_a’: ‘inhibition’}
negative allosteric modulation A causal mechanism in which the effector reduces or prevents the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition)   {‘is_a’: ‘inhibition’}
agonism A causal mechanism in which the effector binds and activates a receptor to mimic the effect of an endogenous ligand.   {‘is_a’: ‘activation’}
molecular channel opening A causal mechanism in which the effector binds to a molecular channel and facilitates transport of ions through it.   {‘is_a’: ‘activation’}
positive allosteric modulation A causal mechanism in which the effector enhances the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition)   {‘is_a’: ‘activation’}
potentiation A causal mechanism in which the effector binds to and enhances or intensifies the effect of some other chemical or drug on its target.   {‘is_a’: ‘binding’}
activation A causal mechanism in which the effector binds to and positively affects the normal functioning of its target.   {‘is_a’: ‘binding’}
inducer A causal mechanism in which the effector binds to and increases the activity/rate of an enzyme that processes drugs in the body.   {‘is_a’: ‘binding’}
transcriptional regulation A causal mechanism mediated by through the control of target gene transcription    
signaling-mediated control A causal mechanism mediated by the activation or control of signaling events that influence the some aspect of the target entity (e.g. its activity, processing, transport, etc)