Class: CausalMechanismQualifierEnum
URI: biolink:CausalMechanismQualifierEnum
Other properties
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Permissible Values
| Text | Description | Meaning | Other Information |
|---|---|---|---|
| binding | A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction. | ||
| inhibition | A causal mechanism in which the effector binds to the target and negatively effects its normal function, e.g. prevention of enzymatic reaction or activation of downstream pathway. | {‘is_a’: ‘binding’, ‘close_mappings’: [‘DGIdb:inhibitor’, ‘SEMMEDDB:INHIBITS’], ‘narrow_mappings’: [‘DGIdb:blocker’, ‘DGIdb:channel_blocker’, ‘DGIdb:gating_inhibitor’, ‘CHEMBL.MECHANISM:antisense_inhibitor’, ‘CHEMBL.MECHANISM:blocker’, ‘CHEMBL.MECHANISM:inhibitor’, ‘CHEMBL.MECHANISM:negative_allosteric_modulator’, ‘CHEMBL.MECHANISM:negative_modulator’, ‘DGIdb:negative_modulator’]} | |
| antibody_inhibition | A causal mechanism in which an antibody specifically binds to and interferes with the target. | {‘is_a’: ‘inhibition’} | |
| antagonism | A causal mechanism in which the effector binds to a receptor and prevents activation by an agonist through competing for the binding site. | {‘is_a’: ‘inhibition’, ‘close_mappings’: [‘DGIdb:antagonist’, ‘CHEMBL.MECHANISM:antagonist’], ‘narrow_mappings’: [‘CHEMBL.MECHANISM:allosteric_antagonist’]} | |
| molecular_channel_blockage | A causal mechanism in which the effector binds to a molecular channel and prevents or reduces transport of ions through it. | {‘is_a’: ‘inhibition’} | |
| inverse_agonism | A causal mechanism in which the effector binds to the same receptor-binding site as an agonist and antagonizes its effects, often exerting the opposite effect of the agonist by suppressing spontaneous receptor signaling. | {‘is_a’: ‘inhibition’, ‘close_mappings’: [‘CHEMBL.MECHANISM:inverse_agonist’, ‘DGIdb:inverse_agonist’]} | |
| negative_allosteric_modulation | A causal mechanism in which the effector reduces or prevents the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition) | {‘is_a’: ‘inhibition’, ‘close_mappings’: [‘CHEMBL.MECHANISM:negative_allosteric_modulator’, ‘DGIdb:inhibitory_allosteric_modulator’], ‘narrow_mappings’: [‘DGIdb:negative_modulator’]} | |
| agonism | A causal mechanism in which the effector binds and activates a receptor to mimic the effect of an endogenous ligand. | {‘is_a’: ‘activation’, ‘close_mappings’: [‘CHEMBL.MECHANISM:agonist’, ‘DGIdb:agonist’], ‘narrow_mappings’: [‘CHEMBL.MECHANISM:partial_agonist’, ‘DGIdb:partial_agonist’]} | |
| molecular_channel_opening | A causal mechanism in which the effector binds to a molecular channel and facilitates transport of ions through it. | {‘is_a’: ‘activation’, ‘close_mappings’: [‘CHEMBL.MECHANISM:opener’]} | |
| positive_allosteric_modulation | A causal mechanism in which the effector enhances the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition) | {‘is_a’: ‘activation’, ‘close_mappings’: [‘CHEMBL.MECHANISM:positive_allosteric_modulator’, ‘CHEMBL.MECHANISM:positive_modulator’, ‘DGIdb:positive_allosteric_modulator’], ‘broad_mappings’: [‘DGIdb:modulator’, ‘DGIdb:allosteric_modulator’]} | |
| potentiation | A causal mechanism in which the effector binds to and enhances or intensifies the effect of some other chemical or drug on its target. | {‘is_a’: ‘binding’} | |
| activation | A causal mechanism in which the effector binds to and positively affects the normal functioning of its target. | {‘is_a’: ‘binding’, ‘close_mappings’: [‘CHEMBL.MECHANISM:activator’, ‘DGIdb:activator’]} | |
| inducer | A causal mechanism in which the effector binds to and increases the activity/rate of an enzyme that processes drugs in the body. | {‘is_a’: ‘binding’, ‘close_mappings’: [‘DGIdb:inducer’]} | |
| transcriptional_regulation | A causal mechanism mediated by through the control of target gene transcription | ||
| signaling_mediated_control | A causal mechanism mediated by the activation or control of signaling events that influence the some aspect of the target entity (e.g. its activity, processing, transport, etc) | ||
| stabilization | {‘is_a’: ‘activation’, ‘close_mappings’: [‘CHEMBL.MECHANISM:stabiliser’]} | ||
| stimulation | {‘is_a’: ‘activation’, ‘close_mappings’: [‘DGIdb:stimulator’, ‘SEMMEDDB:STIMULATES’, ‘DGIdb:stimulator’]} | ||
| releasing_activity | {‘is_a’: ‘activation’, ‘close_mappings’: [‘CHEMBL:MECHANISM:releasing_agent’]} |