Skip to content

Class: GeneRegulatesGeneAssociation

Description: Describes a regulatory relationship between two genes or gene products.
classDiagram class GeneRegulatesGeneAssociation Association <|-- GeneRegulatesGeneAssociation GeneRegulatesGeneAssociation : adjusted_p_value GeneRegulatesGeneAssociation : agent_type GeneRegulatesGeneAssociation --|> AgentTypeEnum : agent_type GeneRegulatesGeneAssociation : aggregator_knowledge_source GeneRegulatesGeneAssociation : category GeneRegulatesGeneAssociation : deprecated GeneRegulatesGeneAssociation : description GeneRegulatesGeneAssociation : has_attribute GeneRegulatesGeneAssociation --|> Attribute : has_attribute GeneRegulatesGeneAssociation : has_evidence GeneRegulatesGeneAssociation --|> EvidenceType : has_evidence GeneRegulatesGeneAssociation : has_supporting_studies GeneRegulatesGeneAssociation --|> Study : has_supporting_studies GeneRegulatesGeneAssociation : id GeneRegulatesGeneAssociation : iri GeneRegulatesGeneAssociation : knowledge_level GeneRegulatesGeneAssociation --|> KnowledgeLevelEnum : knowledge_level GeneRegulatesGeneAssociation : knowledge_source GeneRegulatesGeneAssociation : name GeneRegulatesGeneAssociation : negated GeneRegulatesGeneAssociation : object GeneRegulatesGeneAssociation --|> GeneOrGeneProduct : object GeneRegulatesGeneAssociation : object_aspect_qualifier GeneRegulatesGeneAssociation --|> GeneOrGeneProductOrChemicalEntityAspectEnum : object_aspect_qualifier GeneRegulatesGeneAssociation : object_category GeneRegulatesGeneAssociation --|> OntologyClass : object_category GeneRegulatesGeneAssociation : object_category_closure GeneRegulatesGeneAssociation --|> OntologyClass : object_category_closure GeneRegulatesGeneAssociation : object_closure GeneRegulatesGeneAssociation : object_direction_qualifier GeneRegulatesGeneAssociation --|> DirectionQualifierEnum : object_direction_qualifier GeneRegulatesGeneAssociation : object_label_closure GeneRegulatesGeneAssociation : object_namespace GeneRegulatesGeneAssociation : original_object GeneRegulatesGeneAssociation : original_predicate GeneRegulatesGeneAssociation : original_subject GeneRegulatesGeneAssociation : p_value GeneRegulatesGeneAssociation : predicate GeneRegulatesGeneAssociation : primary_knowledge_source GeneRegulatesGeneAssociation : publications GeneRegulatesGeneAssociation --|> Publication : publications GeneRegulatesGeneAssociation : qualified_predicate GeneRegulatesGeneAssociation : qualifier GeneRegulatesGeneAssociation : qualifiers GeneRegulatesGeneAssociation --|> OntologyClass : qualifiers GeneRegulatesGeneAssociation : retrieval_source_ids GeneRegulatesGeneAssociation --|> RetrievalSource : retrieval_source_ids GeneRegulatesGeneAssociation : species_context_qualifier GeneRegulatesGeneAssociation --|> OrganismTaxon : species_context_qualifier GeneRegulatesGeneAssociation : subject GeneRegulatesGeneAssociation --|> GeneOrGeneProduct : subject GeneRegulatesGeneAssociation : subject_category GeneRegulatesGeneAssociation --|> OntologyClass : subject_category GeneRegulatesGeneAssociation : subject_category_closure GeneRegulatesGeneAssociation --|> OntologyClass : subject_category_closure GeneRegulatesGeneAssociation : subject_closure GeneRegulatesGeneAssociation : subject_label_closure GeneRegulatesGeneAssociation : subject_namespace GeneRegulatesGeneAssociation : timepoint GeneRegulatesGeneAssociation : type

Inheritance

Slots

Name Cardinality and Range Inheritance Examples
object_aspect_qualifier:
the aspect of the object gene or gene product that is being regulated, must be a descendant of "activity_or_abundance""
1
GeneOrGeneProductOrChemicalEntityAspectEnum		 direct stability, abundance, expression, exposure
object_direction_qualifier:
Composes with the core concept (+ aspect if provided) to describe a change in its direction or degree. This qualifier qualifies the object of an association (aka: statement). 		1
DirectionQualifierEnum		 direct
qualified_predicate:
Predicate to be used in an association when subject and object qualifiers are present and the full reading of the statement requires a qualification to the predicate in use in order to refine or increase the specificity of the full statement reading. This qualifier holds a relationship to be used instead of that expressed by the primary predicate, in a ‘full statement’ reading of the association, where qualifier-based semantics are included. This is necessary only in cases where the primary predicate does not work in a full statement reading. 		1
String		 direct
species_context_qualifier:
A statement qualifier representing a taxonomic category of species in which a relationship expressed in an association took place. 		0..1
OrganismTaxon		 direct zebrafish, human
subject:
connects an association to the subject of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
GeneOrGeneProduct		 Association
predicate:
A high-level grouping for the relationship type. AKA minimal predicate. This is analogous to category for nodes. 		1
PredicateType		 Association
object:
connects an association to the object of the association. For example, in a gene-to-phenotype association, the gene is subject and phenotype is object. 		1
GeneOrGeneProduct		 Association
negated:
if set to true, then the association is negated i.e. is not true 		0..1
Boolean		 Association
qualifier:
grouping slot for all qualifiers on an edge. useful for testing compliance with association classes 		0..1
String		 Association
qualifiers:
connects an association to qualifiers that modify or qualify the meaning of that association 		*
OntologyClass		 Association
publications:
One or more publications that report the statement expressed in an Association, or provide information used as evidence supporting this statement. 		*
Publication		 Association
has_evidence:
connects an association to an instance of supporting evidence 		*
EvidenceType		 Association
knowledge_source:
An Information Resource from which the knowledge expressed in an Association was retrieved, directly or indirectly. This can be any resource through which the knowledge passed on its way to its currently serialized form. In practice, implementers should use one of the more specific subtypes of this generic property. 		0..1
String		 Association
primary_knowledge_source:
The most upstream source of the knowledge expressed in an Association that an implementer can identify. Performing a rigorous analysis of upstream data providers is expected; every effort is made to catalog the most upstream source of data in this property. Only one data source should be declared primary in any association. "aggregator knowledge source" can be used to capture non-primary sources. 		0..1
String		 Association
aggregator_knowledge_source:
An intermediate aggregator resource from which knowledge expressed in an Association was retrieved downstream of the original source, on its path to its current serialized form. 		*
String		 Association
knowledge_level:
Describes the level of knowledge expressed in a statement, based on the reasoning or analysis methods used to generate the statement, or the scope or specificity of what the statement expresses to be true. 		1
KnowledgeLevelEnum		 Association knowledge_assertion, prediction, statistical_association
agent_type:
Describes the high-level category of agent who originally generated a statement of knowledge or other type of information. 		1
AgentTypeEnum		 Association manual_agent, automated_agent, computational_model, text_mining_agent
timepoint:
a point in time 		0..1
TimeType		 Association
original_subject:
used to hold the original subject of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
String		 Association
original_predicate:
used to hold the original relation/predicate that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
Uriorcurie		 Association
original_object:
used to hold the original object of a relation (or predicate) that an external knowledge source uses before transformation to match the biolink-model specification. 		0..1
String		 Association
subject_category:
Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
OntologyClass		 Association biolink:Gene
object_category:
Used to hold the biolink class/category of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
OntologyClass		 Association biolink:Disease
subject_closure:
Used to hold the subject closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association
object_closure:
Used to hold the object closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association ['MONDO:0000167', 'MONDO:0005395']
subject_category_closure:
Used to hold the subject category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
OntologyClass		 Association ['biolink:Gene", "biolink:NamedThing']
object_category_closure:
Used to hold the object category closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
OntologyClass		 Association ['biolink:Disease", "biolink:NamedThing']
subject_namespace:
Used to hold the subject namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
String		 Association NCBIGene
object_namespace:
Used to hold the object namespace of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		0..1
String		 Association MONDO
subject_label_closure:
Used to hold the subject label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association ['BRACA1']
object_label_closure:
Used to hold the object label closure of an association. This is a denormalized field used primarily in the SQL serialization of a knowledge graph via KGX. 		*
String		 Association breast cancer, cancer
retrieval_source_ids:
A list of retrieval sources that served as a source of knowledge expressed in an Edge, or a source of data used to generate this knowledge. 		*
RetrievalSource		 Association
p_value:
A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone. 		0..1
Float		 Association
adjusted_p_value:
The adjusted p-value is the probability of obtaining test results at least as extreme as the results actually observed, under the assumption that the null hypothesis is correct, adjusted for multiple comparisons. P is always italicized and capitalized. The actual P value* should be expressed (P=. 04) rather than expressing a statement of inequality (P<. 05), unless P<. 		0..1
Float		 Association
has_supporting_studies:
A study that produced information used as evidence to generate the knowledge expressed in an Association. 		*
Study		 Association
id:
A unique identifier for an entity. Must be either a CURIE shorthand for a URI or a complete URI 		1
String		 Entity
iri:
An IRI for an entity. This is determined by the id using expansion rules. 		0..1
IriType		 Entity
category:
Name of the high level ontology class in which this entity is categorized. Corresponds to the label for the biolink entity type class. In a neo4j database this MAY correspond to the neo4j label tag. In an RDF database it should be a biolink model class URI. This field is multi-valued. It should include values for ancestors of the biolink class; for example, a protein such as Shh would have category values biolink:Protein, biolink:GeneProduct, biolink:MolecularEntity. In an RDF database, nodes will typically have an rdf:type triples. This can be to the most specific biolink class, or potentially to a class more specific than something in biolink. For example, a sequence feature f may have a rdf:type assertion to a SO class such as TF_binding_site, which is more specific than anything in biolink. Here we would have categories {biolink:GenomicEntity, biolink:MolecularEntity, biolink:NamedThing} 		*
Uriorcurie		 Entity
type:
rdf:type of biolink:Association should be fixed at rdf:Statement 		*
String		 Entity
name:
A human-readable name for an attribute or entity. 		0..1
LabelType		 Entity
description:
a human-readable description of an entity 		0..1
NarrativeText		 Entity
has_attribute:
connects any entity to an attribute 		*
Attribute		 Entity
deprecated:
A boolean flag indicating that an entity is no longer considered current or valid. 		0..1
Boolean		 Entity

Example values

Slot Name Value
GeneRegulatesGeneAssociation JsonObj(subject='NCBIGene:551', predicate='regulates', qualified_predicte='causes', object='NCBIGene:1636', object_aspect_qualifier='activity_or_abundance', object_direction_qualifier='downregulated')

LinkML Source

name: gene regulates gene association
description: Describes a regulatory relationship between two genes or gene products.
examples:
- value: JsonObj(subject='NCBIGene:551', predicate='regulates', qualified_predicte='causes',
    object='NCBIGene:1636', object_aspect_qualifier='activity_or_abundance', object_direction_qualifier='downregulated')
from_schema: https://w3id.org/biolink/biolink-model
is_a: association
slots:
- object aspect qualifier
- object direction qualifier
- qualified predicate
- species context qualifier
slot_usage:
  subject:
    name: subject
    range: gene or gene product
  predicate:
    name: predicate
    id_prefixes:
    - regulates
  object:
    name: object
    range: gene or gene product
  object aspect qualifier:
    name: object aspect qualifier
    description: the aspect of the object gene or gene product that is being regulated,
      must be a descendant of  "activity_or_abundance""
    range: GeneOrGeneProductOrChemicalEntityAspectEnum
    required: true
  object direction qualifier:
    name: object direction qualifier
    range: DirectionQualifierEnum
    required: true
  qualified predicate:
    name: qualified predicate
    subproperty_of: causes
    required: true